Fig. 1 · Structure
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MDR-652
Cat. No.
A68732
CAS
1933528-96-1
TRPV1 Agonist
MDR-652 is a targeted agonist of the transient receptor potential vanilloid 1 (TRPV1) channel. This compound displays high specificity with binding affinities (Kis) of 11.4 nM for human TRPV1 and 23.8 nM for rat TRPV1. The effective concentrations (EC50s) are 5.05 nM and 93 nM for hTRPV1 and rTRPV1, respectively. MDR-652 demonstrates significant potential as a topical analgesic, making it a valuable tool in pain research and therapeutic applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1933528-96-1 |
| Applications | TRPV1 Agonist |
| Formula | C22H23ClFN3O2S |
| Molecular Weight | 447.95 |
| SMILES | O=C(NC1=CC=C(CO)C(F)=C1)NCC2=C(C3=CC=CC(Cl)=C3)N=C(C(C)(C)C)S2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.