MEN-91507 is a potent orally active antagonist of the cysteinyl leukotriene receptor 1 (CysLTR1). It effectively inhibits calcium transients induced by Leukotriene D4, exhibiting an insurmountable antagonistic behavior with a pKb of 10.25. MEN-91507 demonstrates significant efficacy in blocking Leukotriene D4-induced bronchoconstriction and microvascular leakage in guinea pig models. This compound is suitable for research applications in the fields of inflammation and immunology.
MEN-91507 is a potent orally active antagonist of the cysteinyl leukotriene receptor 1 (CysLTR1). It effectively inhibits calcium transients induced by Leukotriene D4, exhibiting an insurmountable antagonistic behavior with a pKb of 10.25. MEN-91507 demonstrates significant efficacy in blocking Leukotriene D4-induced bronchoconstriction and microvascular leakage in guinea pig models. This compound is suitable for research applications in the fields of inflammation and immunology.
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