Methotrexate (Abitrexate)

Catalog No.: A10021

DHFR inhibitor

Methotrexate (Abitrexate)

Methotrexate (Abitrexate) Chemical Structure

CAS NO. CAS: 59-05-2

Methotrexate is a cytotoxic agent that inhibits thymidylate synthetase and de novo purine synthesis.

Availability: In stock

Package Price Qty
100 mg

Regular Price: $50.00

Special Price $45.00

200 mg

Regular Price: $75.00

Special Price $67.50

500 mg

Regular Price: $130.00

Special Price $117.00

10mM * 1mL in DMSO

Regular Price: $61.00

Special Price $54.90

Warning WARNING: Attention California Residents: This product can expose you to chemicals including Adriamycin, which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Methotrexate is a cytotoxic agent that inhibits thymidylate synthetase and de novo purine synthesis.
In vitro (25°C) DMSO 90 mg/mL (198.04 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.01 mL 110.03 mL 220.05 mL
0.5 mM 4.4 mL 22.01 mL 44.01 mL
1 mM 2.2 mL 11 mL 22.01 mL
5 mM 0.44 mL 2.2 mL 4.4 mL

*The above data is based on the productmolecular weight 454.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A10021
Actions Inhibitor
M. Wt 454.44
Formula C20H22N8O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. CAS: 59-05-2
Synonyms MTX, amethopterin, Abitrexate, Rheumatrex, Trexall
SMILES CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[[email protected]@H](CCC(=O)O)C(=O)O

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