Methotrexate (Abitrexate)

Catalog No.: A10021

DHFR inhibitor

Methotrexate (Abitrexate)

Methotrexate (Abitrexate) Chemical Structure

CAS NO. CAS: 59-05-2

Methotrexate is a cytotoxic agent that inhibits thymidylate synthetase and de novo purine synthesis.

Availability: In stock

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100 mg
200 mg
500 mg
10mM * 1mL in DMSO
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Warning WARNING: Attention California Residents: This product can expose you to chemicals including Methotrexate (Abitrexate) , which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Methotrexate is a cytotoxic agent that inhibits thymidylate synthetase and de novo purine synthesis.
In vitro (25°C) DMSO Warmed: 89 mg/mL (195.84 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.01 mL 110.03 mL 220.05 mL
0.5 mM 4.4 mL 22.01 mL 44.01 mL
1 mM 2.2 mL 11 mL 22.01 mL
5 mM 0.44 mL 2.2 mL 4.4 mL

*The above data is based on the productmolecular weight 454.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10021
Actions Inhibitor
CAS No. CAS: 59-05-2
Formula C20H22N8O5
M. Wt 454.44
Purity >98%
Synonyms MTX, amethopterin, Abitrexate, Rheumatrex, Trexall
SMILES CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[[email protected]@H](CCC(=O)O)C(=O)O

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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