Methyl 6-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate is a selective inhibitor of Janus Kinases (JAK) with demonstrated IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3. This compound effectively inhibits IL-12 production in human whole blood, with an IC50 of 28 nM. It is poised for applications in cancer research and may provide insight into the modulation of signaling pathways mediated by JAK kinases.
Methyl 6-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate is a selective inhibitor of Janus Kinases (JAK) with demonstrated IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3. This compound effectively inhibits IL-12 production in human whole blood, with an IC50 of 28 nM. It is poised for applications in cancer research and may provide insight into the modulation of signaling pathways mediated by JAK kinases.
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![Methyl 6-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate 2127110-22-7 JAK Inhibitor](https://www.adooq.com/media/catalog/product/cache/9222bce87e7def4079ba2ab8616be292/a/3/a33277-methyl-6-1-4-methoxybenzyl-1h-pyrazol-4-yl-4-oxo-4-5-dihydropyrazolo-1-5-a-pyrazine-2-carboxylate.gif)
