Metyrapone

Catalog No.: A13363

Cytochrome P450 inhibitor

Metyrapone

Metyrapone Chemical Structure

CAS NO. 54-36-4

Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.

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  • Vera-Chang MN, .et al. Transgenerational hypocortisolism and behavioral disruption are induced by the antidepressant fluoxetine in male zebrafish Danio rerio, Proc Natl Acad Sci U S A, 2018, Dec 10. pii: 201811695 PMID: 30530669
  • Tea J, .et al. Social stress increases plasma cortisol and reduces forebrain cell proliferation in subordinate male zebrafish (Danio rerio), J Exp Biol, 2018, Dec 10. pii: jeb.194894 PMID: 30530837

Biological Activity

Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.
In vitro DMSO 44 mg/mL (194.45 mM)
Ethanol <1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 44.19 mL 220.97 mL 441.95 mL
0.5 mM 8.84 mL 44.19 mL 88.39 mL
1 mM 4.42 mL 22.1 mL 44.19 mL
5 mM 0.88 mL 4.42 mL 8.84 mL

*The above data is based on the productmolecular weight 226.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13363
Actions Inhibitor
CAS No. 54-36-4
Formula C14H14N2O
M. Wt 226.27
Purity >98%
SMILES CC(C)(C1=CN=CC=C1)C(=O)C2=CN=CC=C2
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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