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- Paudel DB, .et al. Expression and antiviral function of ARGONAUTE 2 in Nicotiana benthamiana plants infected with two isolates of tomato ringspot virus with varying degrees of virulence, Virology, 2018, Nov;524:127-139 PMID: 30195250
- Ohkusu-Tsukada K, .et al. The Role of Proteasome Inhibitor MG132 in 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis in NC/Nga Mice, Int Arch Allergy Immunol, 2018, 176(2):91-100 PMID: 29669333
- Chi-Hung R. Or, .et al. Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells, Int J Mol Sci, 2016, Jan; 18(1): 44 PMID: 28035994
|Storage||at -20°C 3 years Powder|
|Synonyms||Z-Leu-Leu-Leu-CHO, Z-LLL-CHO, MG132|
|SMILES||CC(C)C[[email protected]@H](C=O)NC(=O)[[email protected]](CC(C)C)NC(=O)[[email protected]](CC(C)C)NC(=O)OCC1=CC=CC=C1|
|MG-132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM).|
|Solubility (25°C) *||In vitro||DMSO||95 mg/mL (199.73 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||95 mg/mL (199.73 mM)|
|In vivo||1% DMSO/30% polyethylene glycol/1% Tween 80, pH 4||6 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||21.03 mL||105.13 mL||210.26mL|
|0.5 mM||4.21 mL||21.03 mL||42.05 mL|
|1 mM||2.1 mL||10.51 mL||21.03 mL|
|5 mM||0.42 mL||2.1 mL||4.21 mL|
*The above data is based on the productmolecular weight 475.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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