MG-132

Catalog No.: A11043

Proteasome inhibitor

MG-132

MG-132 Chemical Structure

CAS NO. 133407-82-6

MG-132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM).

Availability: In stock

Package Price Qty
10 mg
$50.00
25 mg
$120.00
50 mg
$200.00
100 mg
$270.00
10mM * 1mL in DMSO
$65.00
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  • Hua Xu, .et al. Preclinical Study Using ABT263 to Increase Enzalutamide Sensitivity to Suppress Prostate Cancer Progression Via Targeting BCL2/ROS/USP26 Axis Through Altering ARv7 Protein Degradation, Cancers (Basel), 2020, Apr; 12(4): 831 PMID: 32235588
  • Ghosh S, .et al. Interactions between Viperin, Vesicle-Associated Membrane Protein A, and Hepatitis C Virus Protein NS5A Modulate Viperin Activity and NS5A Degradation, Biochemistry, 2020, Feb 18;59(6):780-789 PMID: 31977203
  • Chi-Hung R Or, .et al. Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling, Int J Mol Sci, 2020, Mar 5;21(5):1773 PMID: 32150830
  • Kondo H, .et al. PITHD1 is a proteasome-interacting protein essential for male fertilization, J Biol Chem, 2020, Feb 7;295(6):1658-1672 PMID: 31915251
  • Ohigashi I, .et al. Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells, Cell Rep, 2019, Nov 26;29(9):2901-2916 PMID: 31775054
  • Ohkusu-Tsukada K, .et al. The Role of Proteasome Inhibitor MG132 in 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis in NC/Nga Mice, Int Arch Allergy Immunol, 2018, 176(2):91-100 PMID: 29669333
  • Paudel DB, .et al. Expression and antiviral function of ARGONAUTE 2 in Nicotiana benthamiana plants infected with two isolates of tomato ringspot virus with varying degrees of virulence, Virology, 2018, Nov;524:127-139 PMID: 30195250
  • Chi-Hung R. Or, .et al. Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells, Int J Mol Sci, 2016, Jan; 18(1): 44 PMID: 28035994

Biological Activity

MG-132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM).
Targets
Proteasome (Cell-free assay)
100 nM
In vitro (25°C) DMSO 95 mg/mL (199.73 mM)
Water <1 mg/mL (<1 mM)
Ethanol 95 mg/mL (199.73 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80, pH 4 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.03 mL 105.13 mL 210.26 mL
0.5 mM 4.21 mL 21.03 mL 42.05 mL
1 mM 2.1 mL 10.51 mL 21.03 mL
5 mM 0.42 mL 2.1 mL 4.21 mL

*The above data is based on the productmolecular weight 475.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11043
Actions Inhibitor
M. Wt 475.6
Formula C26H41N3O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 133407-82-6
Synonyms Z-Leu-Leu-Leu-CHO, Z-LLL-CHO, MG132
SMILES CC(C)C[[email protected]@H](C=O)NC(=O)[[email protected]](CC(C)C)NC(=O)[[email protected]](CC(C)C)NC(=O)OCC1=CC=CC=C1

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