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Biological Activity
MG-132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM).
Targets
Proteasome (Cell-free assay) | ||||
100 nM |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 21.03 mL | 105.13 mL | 210.26 mL |
0.5 mM | 4.21 mL | 21.03 mL | 42.05 mL |
1 mM | 2.1 mL | 10.51 mL | 21.03 mL |
5 mM | 0.42 mL | 2.1 mL | 4.21 mL |
*The above data is based on the productmolecular weight 475.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11043 |
---|---|
Actions | Inhibitor |
CAS No. | 133407-82-6 |
Formula | C26H41N3O5 |
M. Wt | 475.6 |
Purity | >98% |
Synonyms | Z-Leu-Leu-Leu-CHO, Z-LLL-CHO, MG132 |
SMILES | CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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