MGD-22 is a molecular glue and an orally active degrader of the IKZF1/2/3 proteins, with DC50 values of 8.33 nM, 9.91 nM, and 5.74 nM, respectively. This compound exhibits significant anti-proliferative effects on various hematological cancer cell lines and induces apoptosis in these cells. Additionally, MGD-22 demonstrates robust anti-tumor efficacy in mouse models with NCI-H929 or WSU-DLCL-2 xenografts. It is a valuable tool for investigating hematological malignancies, particularly multiple myeloma (MM), acute myeloid leukemia (AML), and diffuse large B-cell lymphoma (DLBCL).
MGD-22 is a molecular glue and an orally active degrader of the IKZF1/2/3 proteins, with DC50 values of 8.33 nM, 9.91 nM, and 5.74 nM, respectively. This compound exhibits significant anti-proliferative effects on various hematological cancer cell lines and induces apoptosis in these cells. Additionally, MGD-22 demonstrates robust anti-tumor efficacy in mouse models with NCI-H929 or WSU-DLCL-2 xenografts. It is a valuable tool for investigating hematological malignancies, particularly multiple myeloma (MM), acute myeloid leukemia (AML), and diffuse large B-cell lymphoma (DLBCL).
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