Miltirone is a partial agonist of the central benzodiazepine receptor, exhibiting an IC50 value of 0.3 μM. This natural compound, derived from the root of Salvia miltiorrhiza, demonstrates significant biological activity by inducing ROS- and p53-dependent apoptosis. Additionally, Miltirone effectively inhibits carboxylesterase 2 (CES2) with a Ki of 0.04 μM and the main protease (Mpro) of SARS-CoV, making it valuable for research involving apoptosis, enzymatic regulation, and virology.
Miltirone is a partial agonist of the central benzodiazepine receptor, exhibiting an IC50 value of 0.3 μM. This natural compound, derived from the root of Salvia miltiorrhiza, demonstrates significant biological activity by inducing ROS- and p53-dependent apoptosis. Additionally, Miltirone effectively inhibits carboxylesterase 2 (CES2) with a Ki of 0.04 μM and the main protease (Mpro) of SARS-CoV, making it valuable for research involving apoptosis, enzymatic regulation, and virology.
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