MK-0517 (Fosaprepitant)

Catalog No.: A11756

neurokinin-1 receptor antagonist

MK-0517 (Fosaprepitant)

MK-0517 (Fosaprepitant) Chemical Structure

CAS NO. 172673-20-0

Fosaprepitant (MK-0517, L-758,298) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist.

Availability: In stock

Package Price Qty
5 mg
$80.00
10 mg
$140.00
25 mg
$250.00
50 mg
$450.00
10mM * 1mL in DMSO
$157.00
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Biological Activity

Fosaprepitant (MK-0517, L-758,298) is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.28 mL 81.38 mL 162.76 mL
0.5 mM 3.26 mL 16.28 mL 32.55 mL
1 mM 1.63 mL 8.14 mL 16.28 mL
5 mM 0.33 mL 1.63 mL 3.26 mL

*The above data is based on the productmolecular weight 614.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11756
Actions Antagonist
CAS No. 172673-20-0
Formula C23H22F7N4O6P
M. Wt 614.41
Purity >98%
Synonyms MK-0517, L-758,298
SMILES C[[email protected]](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[[email protected]@H]2[[email protected]@H](N(CCO2)CC3=NC(=O)N(N3)P(=O)(O)O)C4=CC=C(C=C4)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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