MK-1775

Catalog No.: A10599

WEE1 Inhibitor

MK-1775

MK-1775 Chemical Structure

CAS NO. 955365-80-7

MK-1775 is a potent and selective Wee1 kinase inhibitor in vitro and in vivo.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $45.00

Special Price $36.00

10 mg

Regular Price: $75.00

Special Price $60.00

50 mg

Regular Price: $135.00

Special Price $108.00

10mM * 1mL in DMSO

Regular Price: $70.00

Special Price $56.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • 2018, .et al. Augmentation of the therapeutic efficacy of WEE1 kinase inhibitor AZD1775 by inhibiting the YAP-E2F1-DNA damage response pathway axis, FEBS Open Bio, 2018, Jun; 8(6): 1001-1012 PMID: 29928579
  • Rulina AV, .et al. Distinct outcomes of CRL-Nedd8 pathway inhibition reveal cancer cell plasticity, Cell Death Dis, 2016, Dec 1;7(12):e2505 PMID: 27906189

Biological Activity

MK-1775 is a potent and selective Wee1 kinase inhibitor in vitro and in vivo.
Targets
Wee1 (Cell-free assay)
5.2 nM
In vitro (25°C) DMSO 71 mg/mL (141.82 mM)
Water Insoluble
Ethanol 9 mg/mL (17.97 mM)
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.98 mL 99.88 mL 199.76 mL
0.5 mM 4 mL 19.98 mL 39.95 mL
1 mM 2 mL 9.99 mL 19.98 mL
5 mM 0.4 mL 2 mL 4 mL

*The above data is based on the productmolecular weight 500.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10599
Actions Inhibitor
CAS No. 955365-80-7
Formula C27H32N8O2
M. Wt 500.6
Purity >98%
Synonyms MK1775,MK 1775, AZD-1775, AZD1775
SMILES CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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