Adavosertib (MK-1775)
MK-1775 is a potent and selective Wee1 kinase inhibitor in vitro and in vivo.
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Adooq Products cited in reputable paper
Adooq's Adavosertib (MK-1775) has been cited by 5 publications
- Hayden L Bell, .et al. , Cancer Cell Int, 2023, Sep 15;23(1):202 PMID: 37715172
- Chiao-Ping Chen, .et al. , Biomed Pharmacother, 2023, Oct:166:115389 PMID: 37659202
- Ting-Yu Chang, .et al. , Biomed Pharmacother, 2021, Jun;138:111485 PMID: 33740521
- 2018, .et al. , FEBS Open Bio, 2018, Jun; 8(6): 1001-1012 PMID: 29928579
- Rulina AV, .et al. , Cell Death Dis, 2016, Dec 1;7(12):e2505 PMID: 27906189
Biological Activity
| Description | MK-1775 is a potent and selective Wee1 kinase inhibitor in vitro and in vivo. | |||||
|---|---|---|---|---|---|---|
| Targets |
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| Cell Research |
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Product Information
| Catalog Num | A10599 |
|---|---|
| Formula | C27H32N8O2 |
| Molecular Weight | 500.6 |
| CAS Number | 955365-80-7 |
| SMILES | CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O |
| Synonyms | AZD1775 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro (25°C) | DMSO | 71 mg/mL (141.82 mM) | |
| Water | Insoluble | ||
| Ethanol | 9 mg/mL (17.97 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.98 mL | 99.88 mL | 199.76 mL |
| 0.5 mM | 4 mL | 19.98 mL | 39.95 mL |
| 1 mM | 2 mL | 9.99 mL | 19.98 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
