MK-5596 is a selective and orally active inverse agonist of the cannabinoid receptor 1 (CB1R), exhibiting an IC50 of 1.0 nM and an EC50 of 5.8 nM. This compound demonstrates significant biological activity in promoting weight loss and appetite suppression. Additionally, MK-5596 exhibits mild inhibitory effects on several cytochrome P450 enzymes, including CYP3A4, CYP2C8, CYP2C9, and CYP2D6, with IC50 values ranging from 3.3 to 18 μM. This reagent is primarily utilized in research focused on obesity and its associated metabolic disorders.
MK-5596 is a selective and orally active inverse agonist of the cannabinoid receptor 1 (CB1R), exhibiting an IC50 of 1.0 nM and an EC50 of 5.8 nM. This compound demonstrates significant biological activity in promoting weight loss and appetite suppression. Additionally, MK-5596 exhibits mild inhibitory effects on several cytochrome P450 enzymes, including CYP3A4, CYP2C8, CYP2C9, and CYP2D6, with IC50 values ranging from 3.3 to 18 μM. This reagent is primarily utilized in research focused on obesity and its associated metabolic disorders.
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