MKK7-JNK Activator 1 is a potent activator of the MKK7-JNK signaling pathway. This compound effectively inhibits the proliferation and migration of MDA-MB-468 cells, while also triggering G2/M phase cell cycle arrest and caspase-dependent apoptosis, independent of reactive oxygen species (ROS) production. Notably, MKK7-JNK Activator 1 significantly increases the phosphorylation levels of MKK7 and JNK without affecting ERK or p38 phosphorylation. This reagent is valuable for studying mechanisms relevant to triple-negative breast cancer (TNBC).
MKK7-JNK Activator 1 is a potent activator of the MKK7-JNK signaling pathway. This compound effectively inhibits the proliferation and migration of MDA-MB-468 cells, while also triggering G2/M phase cell cycle arrest and caspase-dependent apoptosis, independent of reactive oxygen species (ROS) production. Notably, MKK7-JNK Activator 1 significantly increases the phosphorylation levels of MKK7 and JNK without affecting ERK or p38 phosphorylation. This reagent is valuable for studying mechanisms relevant to triple-negative breast cancer (TNBC).
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