MKP10241 is an orally active agonist of GPR119, a G protein-coupled receptor involved in the regulation of glucose metabolism. This compound significantly elevates cAMP levels in GPR119-expressing cell lines, demonstrating an EC50 of 3.7 nM. MKP10241 effectively lowers blood glucose levels and HbA1c in both acute and chronic diabetic mouse models, and exhibits promising preclinical efficacy in addressing obesity and metabolic associated steatotic hepatitis (MASH) in rodent studies.
MKP10241 is an orally active agonist of GPR119, a G protein-coupled receptor involved in the regulation of glucose metabolism. This compound significantly elevates cAMP levels in GPR119-expressing cell lines, demonstrating an EC50 of 3.7 nM. MKP10241 effectively lowers blood glucose levels and HbA1c in both acute and chronic diabetic mouse models, and exhibits promising preclinical efficacy in addressing obesity and metabolic associated steatotic hepatitis (MASH) in rodent studies.
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