ML-184 is a selective agonist for the GPR55 receptor, exhibiting an EC50 value of 250 nM and demonstrating over 100-fold selectivity for GPR55 compared to GPR35, CB1, and CB2. This compound triggers phosphorylation of ERK1/2 and facilitates the translocation of PKCβII to the plasma membrane through GPR55 activation. Additionally, ML-184 enhances the proliferation of neural stem cells and promotes neuronal differentiation in vitro, making it a valuable tool for research in neurobiology and cellular signaling pathways.
ML-184 is a selective agonist for the GPR55 receptor, exhibiting an EC50 value of 250 nM and demonstrating over 100-fold selectivity for GPR55 compared to GPR35, CB1, and CB2. This compound triggers phosphorylation of ERK1/2 and facilitates the translocation of PKCβII to the plasma membrane through GPR55 activation. Additionally, ML-184 enhances the proliferation of neural stem cells and promotes neuronal differentiation in vitro, making it a valuable tool for research in neurobiology and cellular signaling pathways.
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