ML 297 is a potent and selective activator of GIRK1/2 channels, exhibiting an EC50 of 0.16 μM. This compound effectively crosses the blood-brain barrier, demonstrated by a brain-to-plasma ratio of 0.2 in murine models following intraperitoneal administration. ML 297 is under investigation for its potential therapeutic applications in the treatment of epilepsy.
ML 297 is a potent and selective activator of GIRK1/2 channels, exhibiting an EC50 of 0.16 μM. This compound effectively crosses the blood-brain barrier, demonstrated by a brain-to-plasma ratio of 0.2 in murine models following intraperitoneal administration. ML 297 is under investigation for its potential therapeutic applications in the treatment of epilepsy.
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