ML334 is a potent NRF2 activator that functions by inhibiting the Keap1-NRF2 protein-protein interaction. With a binding affinity to the Keap1 Kelch domain of 1 μM, ML334 effectively promotes NRF2 expression and its subsequent nuclear translocation, thereby enhancing antioxidant response element (ARE) activity. This compound is valuable for research applications focused on oxidative stress, neuroprotection, and cellular responses to environmental stimuli.
ML334 is a potent NRF2 activator that functions by inhibiting the Keap1-NRF2 protein-protein interaction. With a binding affinity to the Keap1 Kelch domain of 1 μM, ML334 effectively promotes NRF2 expression and its subsequent nuclear translocation, thereby enhancing antioxidant response element (ARE) activity. This compound is valuable for research applications focused on oxidative stress, neuroprotection, and cellular responses to environmental stimuli.
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