MLN4924 (Pevonedistat)

Catalog No.: A11260

NAE Inhibitor

MLN4924 (Pevonedistat)

MLN4924 (Pevonedistat) Chemical Structure

CAS NO. 905579-51-3

NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$140.00
25 mg
$280.00
50 mg
$450.00
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  • Stephan Riesenberg, .et al. Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells, Nat Commun, 2018, 9: 2164 PMID: 29867139
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Richard J. Kraus, .et al. Hypoxia-inducible factor-1?? plays roles in Epstein-Barr virus-s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter, PLoS Pathog, 2017, Jun; 13(6): e1006404 PMID: 28617871

Biological Activity

NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.55 mL 112.74 mL 225.48 mL
0.5 mM 4.51 mL 22.55 mL 45.1 mL
1 mM 2.25 mL 11.27 mL 22.55 mL
5 mM 0.45 mL 2.25 mL 4.51 mL

*The above data is based on the productmolecular weight 443.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11260
Actions Inhibitor
M. Wt 443.5
Formula C21H25N5O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 905579-51-3
Synonyms MLN-4924
SMILES C1CC2=CC=CC=C2[[email protected]]1NC3=NC=NC4=C3C=CN4[[email protected]@H]5C[[email protected]]([[email protected]](C5)O)COS(=O)(=O)N

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