Total item
Cart Subtotal
$0.00 Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
- Corentin Mallet, .et al. Hypoxia and HIF-1 Trigger Marek's Disease Virus Reactivation in Lymphoma-Derived Latently Infected T Lymphocytes, J Virol, 2021, Dec 22;JVI0142721 PMID: 34936483
- Nobuyuki Shimizu, .et al. PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates, Commun Biol, 2021, Nov 11;4(1):1277 PMID: 34764413
- Jalila Chagraoui, .et al. UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex, Cell Stem Cell, 2021, Jan 7;28(1):48-62.e6 PMID: 33417871
- Stephan Riesenberg, .et al. Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells, Nat Commun, 2018, 9: 2164 PMID: 29867139
- Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
- Richard J. Kraus, .et al. Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus??s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter, PLoS Pathog, 2017, Jun; 13(6): e1006404 PMID: 28617871
Biological Activity
NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival.
| In vitro (25°C) | DMSO | 78 mg/mL (175.86 mM) | |
| Water | Insoluble | ||
| Ethanol | 78 mg/mL | ||
| In vivo | 5% DMSO+30% PEG 300+5% Tween 80+ddH2O | 19 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.55 mL | 112.74 mL | 225.48 mL |
| 0.5 mM | 4.51 mL | 22.55 mL | 45.1 mL |
| 1 mM | 2.25 mL | 11.27 mL | 22.55 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.51 mL |
*The above data is based on the productmolecular weight 443.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11260 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 905579-51-3 |
| Formula | C21H25N5O4S |
| M. Wt | 443.5 |
| Purity | >98% |
| Synonyms | MLN-4924 |
| SMILES | C1CC2=CC=CC=C2[C@H]1NC3=NC=NC4=C3C=CN4[C@@H]5C[C@H]([C@H](C5)O)COS(=O)(=O)N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
Keywords:buy MLN4924 (Pevonedistat) | MLN4924 (Pevonedistat) Supplier | purchase | cost | manufacturer | order | distributor | buy 905579-51-3| 905579-51-3 Supplier | purchase 905579-51-3 | 905579-51-3 cost | 905579-51-3 manufacturer | order 905579-51-3 | 905579-51-3 distributor
Adooq Quality Guarantee
We promise all products perform as described.