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MLN4924 (Pevonedistat)

Catalog No.: A11260

NAE Inhibitor

MLN4924 (Pevonedistat)

MLN4924 (Pevonedistat) Chemical Structure

CAS NO. 905579-51-3

NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival.

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  • Corentin Mallet, .et al. Hypoxia and HIF-1 Trigger Marek's Disease Virus Reactivation in Lymphoma-Derived Latently Infected T Lymphocytes, J Virol, 2021, Dec 22;JVI0142721 PMID: 34936483
  • Nobuyuki Shimizu, .et al. PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates, Commun Biol, 2021, Nov 11;4(1):1277 PMID: 34764413
  • Jalila Chagraoui, .et al. UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex, Cell Stem Cell, 2021, Jan 7;28(1):48-62.e6 PMID: 33417871
  • Stephan Riesenberg, .et al. Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells, Nat Commun, 2018, 9: 2164 PMID: 29867139
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Richard J. Kraus, .et al. Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus??s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter, PLoS Pathog, 2017, Jun; 13(6): e1006404 PMID: 28617871

Biological Activity

NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival.
In vitro (25°C) DMSO 78 mg/mL (175.86 mM)
Water Insoluble
Ethanol 78 mg/mL
In vivo 5% DMSO+30% PEG 300+5% Tween 80+ddH2O 19 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.55 mL 112.74 mL 225.48 mL
0.5 mM 4.51 mL 22.55 mL 45.1 mL
1 mM 2.25 mL 11.27 mL 22.55 mL
5 mM 0.45 mL 2.25 mL 4.51 mL

*The above data is based on the productmolecular weight 443.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11260
Actions Inhibitor
CAS No. 905579-51-3
Formula C21H25N5O4S
M. Wt 443.5
Purity >98%
Synonyms MLN-4924
SMILES C1CC2=CC=CC=C2[C@H]1NC3=NC=NC4=C3C=CN4[C@@H]5C[C@H]([C@H](C5)O)COS(=O)(=O)N

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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