MLN4924 (Pevonedistat)

NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival.
Grouped product items
Product Name Price Stock Qty
MLN4924 5mg
$90.00
In stock
MLN4924 10mg
$140.00
In stock
MLN4924 25mg
$280.00
In stock
MLN4924 50mg
$450.00
In stock
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Adooq Products cited in reputable paper
Adooq's MLN4924 (Pevonedistat) has been cited by 9 publications
  • Takumi Ito, .et al. , Research Square, 2023, 2023
  • Blue-leaf A. Cordes, .et al. , Cancers (Basel), 2023, Mar; 15(6): 1846 PMID: 36980731
  • Min Dong, .et al. , J Immunother Cancer, 2022, Oct;10(10):e005270 PMID: 36198437
  • Corentin Mallet, .et al. , J Virol, 2021, Dec 22;JVI0142721 PMID: 34936483
  • Nobuyuki Shimizu, .et al. , Commun Biol, 2021, Nov 11;4(1):1277 PMID: 34764413
  • Jalila Chagraoui, .et al. , Cell Stem Cell, 2021, Jan 7;28(1):48-62.e6 PMID: 33417871
  • Stephan Riesenberg, .et al. , Nat Commun, 2018, 9: 2164 PMID: 29867139
  • Hirosumi Tamura, .et al. , Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Richard J. Kraus, .et al. , PLoS Pathog, 2017, Jun; 13(6): e1006404 PMID: 28617871
  • Biological Activity
    Discription NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival.
    Product Information
    Catalog Num A11260
    Formula C21H25N5O4S
    Molecular Weight 443.5
    CAS Number 905579-51-3
    SMILES C1CC2=CC=CC=C2[C@H]1NC3=NC=NC4=C3C=CN4[C@@H]5C[C@H]([C@H](C5)O)COS(=O)(=O)N
    Synonyms MLN-4924
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 78 mg/mL (175.86 mM)
    Water Insoluble
    Ethanol 78 mg/mL
    In vivo 5% DMSO+30% PEG 300+5% Tween 80+ddH2O 19 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.55 mL 112.74 mL 225.48 mL
    0.5 mM 4.51 mL 22.55 mL 45.1 mL
    1 mM 2.25 mL 11.27 mL 22.55 mL
    5 mM 0.45 mL 2.25 mL 4.51 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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