Catalog No.
Product Name
Application
Product Information
Citations
-
NAE Inhibitor
NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival.- Céline Moison, .et al. , EMBO Rep, 2025, Jun;26(11):2836-2854 PMID: 40295725
- Takumi Ito, .et al. , Research Square, 2023, 2023
- Blue-leaf A. Cordes, .et al. , Cancers (Basel), 2023, Mar; 15(6): 1846 PMID: 36980731
- Min Dong, .et al. , J Immunother Cancer, 2022, Oct;10(10):e005270 PMID: 36198437
- Corentin Mallet, .et al. , J Virol, 2021, Dec 22;JVI0142721 PMID: 34936483
- Nobuyuki Shimizu, .et al. , Commun Biol, 2021, Nov 11;4(1):1277 PMID: 34764413
- Jalila Chagraoui, .et al. , Cell Stem Cell, 2021, Jan 7;28(1):48-62.e6 PMID: 33417871
- Stephan Riesenberg, .et al. , Nat Commun, 2018, 9: 2164 PMID: 29867139
- Hirosumi Tamura, .et al. , Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
- Richard J. Kraus, .et al. , PLoS Pathog, 2017, Jun; 13(6): e1006404 PMID: 28617871
-
NAE Inhibitor
NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival. -
NAE inhibitor
TAS4464 (hydrochloride) is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM. -
NEDD8 Activating Enzyme Inhibitor
ZM223 hydrochloride is a potent non-covalent inhibitor of the NEDD8 activating enzyme (NAE). This compound demonstrates significant anticancer activity, making it a valuable tool in cancer research. Its primary mechanism involves the disruption of NEDD8 conjugation processes, which can lead to altered protein stability and function, thereby influencing various cellular pathways. ZM223 hydrochloride is suitable for investigating the roles of NEDD8 modifications in tumor biology and therapeutic responses.
