NEDD8-activating Enzyme (NAE)

Cat. No.

A11260

CAS No.

905579-51-3

Pevonedistat (MLN4924)

Synonyms: MLN-4924

NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival.

Cat. No.

A11499

CAS No.

1160295-21-5

MLN4924 (HCL Salt)

Synonyms: MLN-4924 HCL

NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival.

Cat. No.

A17174

CAS No.

2031177-48-5

ZM223

ZM223 is a non-sulfamide NEDD8 activating enzyme (NAE) inhibitor that inhibits HCT116 colon cancer cells with an IC50 value of 100 nM.

Cat. No.

A18485

CAS No.

1848959-10-3

TAS4464

TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM.

Cat. No.

A19646

CAS No.

2089293-61-6

NAcM-OPT

NAcM-OPT is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor, which potently inhibits the DCN1-UBE2M interaction.

Cat. No.

A21708

CAS No.

1848959-11-4

TAS4464 hydrochloride

Synonyms: TAS 4464

TAS4464 (hydrochloride) is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM.

Cat. No.

A30872

CAS No.

864420-54-2

NAE-IN-M22

NAE-IN-M22 is a selective and reversible inhibitor of NEDD8 activating enzyme (NAE), exhibiting potency in the micromolar range. This compound demonstrates significant antitumor activity by inhibiting multiple cancer cell lines and inducing apoptosis specifically in A549 cells. Additionally, NAE-IN-M22 has been shown to effectively inhibit tumor growth in vivo, making it a valuable tool for research into cancer biology and therapeutic applications.

Cat. No.

A65466

CAS No.

3058629-66-3

NAE-IN-1

NAE-IN-1 is a potent inhibitor of NAE1, targeting the NEDD8-activating enzyme complex. This compound induces apoptosis and effectively triggers cell cycle arrest at the G2/M phase. Additionally, NAE-IN-1 elevates reactive oxygen species (ROS) levels and inhibits cell migration, demonstrating significant anti-proliferative activity. It serves as a valuable tool for research applications focusing on cancer biology and cell cycle regulation.

Cat. No.

A76948

CAS No.

2438679-27-5

ZM223 hydrochloride

ZM223 hydrochloride is a potent non-covalent inhibitor of the NEDD8 activating enzyme (NAE). This compound demonstrates significant anticancer activity, making it a valuable tool in cancer research. Its primary mechanism involves the disruption of NEDD8 conjugation processes, which can lead to altered protein stability and function, thereby influencing various cellular pathways. ZM223 hydrochloride is suitable for investigating the roles of NEDD8 modifications in tumor biology and therapeutic responses.

Cat. No.

A76949

CAS No.

951950-33-7

NAE-IN-3

NAE-IN-3 is a potent and selective non-covalent inhibitor of the NEDD8-activating enzyme (NAE), demonstrating an IC50 of 0.8 μM. This compound functions by competitively obstructing the ATP-binding domain of NAE, thereby impeding its activity. With a specific focus on NAE, NAE-IN-3 shows minimal interaction with analogous E1 enzymes such as UAE and SAE. This inhibitor is valuable for research aimed at understanding cancer biology and the role of NEDD8 modifications in oncogenesis.