MLN8237 (Alisertib)

Catalog No.: A10004

Aurora A Kinase inhibitor

MLN8237 (Alisertib)

MLN8237 (Alisertib) Chemical Structure

CAS NO. 1028486-01-2

MLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Phase 3..

Availability: In stock

Package Price Qty
5 mg

Regular Price: $60.00

Special Price $48.00

10 mg

Regular Price: $100.00

Special Price $80.00

50 mg

Regular Price: $380.00

Special Price $304.00

200 mg

Regular Price: $950.00

Special Price $760.00

10mM * 1mL in DMSO
$121.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

MLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Phase 3..
In vitro (25°C) DMSO 27 mg/mL (52.03 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.27 mL 96.36 mL 192.72 mL
0.5 mM 3.85 mL 19.27 mL 38.54 mL
1 mM 1.93 mL 9.64 mL 19.27 mL
5 mM 0.39 mL 1.93 mL 3.85 mL

*The above data is based on the productmolecular weight 518.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A10004
Actions Inhibitor
M. Wt 518.9
Formula C27H20ClFN4O4
Solubility DMSO>44mg/mL Water <1mg/mL Ethanol <1mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1028486-01-2
Synonyms N/A
SMILES COC1=C(C(=CC=C1)F)C2=NCC3=CN=C(N=C3C4=C2C=C(C=C4)Cl)NC5=CC(=C(C=C5)C(=O)O)OC

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