Momordicine I is a cucurbitane-type triterpenoid that functions as an apoptosis and autophagy inducer. It effectively suppresses glioma growth by promoting apoptosis and disrupting mitochondrial oxidative phosphorylation. In head and neck cancer cells, Momordicine I inhibits glycolysis and lipid metabolism while stimulating autophagy. Additionally, it alleviates isoproterenol-induced cardiomyocyte hypertrophy by suppressing PLA2G6 and DGK-ζ, offering cardiovascular benefits through the upregulation of nitric oxide and inhibition of angiotensin-converting enzyme (ACE). Momordicine I also shows potential in managing type 2 diabetes by inhibiting AKT1, IL-6, and SRC.
Momordicine I is a cucurbitane-type triterpenoid that functions as an apoptosis and autophagy inducer. It effectively suppresses glioma growth by promoting apoptosis and disrupting mitochondrial oxidative phosphorylation. In head and neck cancer cells, Momordicine I inhibits glycolysis and lipid metabolism while stimulating autophagy. Additionally, it alleviates isoproterenol-induced cardiomyocyte hypertrophy by suppressing PLA2G6 and DGK-ζ, offering cardiovascular benefits through the upregulation of nitric oxide and inhibition of angiotensin-converting enzyme (ACE). Momordicine I also shows potential in managing type 2 diabetes by inhibiting AKT1, IL-6, and SRC.
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