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Monomethyl auristatin E intermediate-1

Catalog No.: A54800
Intermediate Reactant
Monomethyl auristatin E intermediate-1 is a key intermediate reactant used in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor with notable anticancer activity. MMAE serves as the cytotoxic agent in antibody-drug conjugates (ADCs), making it valuable in targeted cancer therapies. This intermediate is essential for the development of innovative ADC formulations aimed at enhancing therapeutic efficacy in oncology research.
Monomethyl auristatin E intermediate-1 120205-48-3 Intermediate Reactant
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Size Price Stock Qty
50mg
$20.00
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100mg
$30.00
In stock
250mg
$50.00
In stock
1g
$125.00
In stock
5g
$375.00
In stock
10g
$595.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMonomethyl auristatin E intermediate-1 is a key intermediate reactant used in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor with notable anticancer activity. MMAE serves as the cytotoxic agent in antibody-drug conjugates (ADCs), making it valuable in targeted cancer therapies. This intermediate is essential for the development of innovative ADC formulations aimed at enhancing therapeutic efficacy in oncology research.
Product Information
Catalog NumA54800
FormulaC14H30ClNO3
Molecular Weight295.85
CAS Number120205-48-3
SMILESCC[C@H](C)[C@H](NC)[C@H](OC)CC(OC(C)(C)C)=O.Cl
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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Cytoskeleton > Microtubule/Tubulin