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Monomethyl auristatin E intermediate-12

Catalog No.: A55038
Intermediate Reactant
Monomethyl auristatin E intermediate-12 serves as an essential intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor known for its anticancer properties. This compound plays a crucial role as the cytotoxic component in antibody-drug conjugates (ADCs), facilitating targeted delivery in cancer therapy. Its use in research applications contributes to the development of innovative therapeutic strategies in oncology.
Monomethyl auristatin E intermediate-12 870640-61-2 Intermediate Reactant
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMonomethyl auristatin E intermediate-12 serves as an essential intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor known for its anticancer properties. This compound plays a crucial role as the cytotoxic component in antibody-drug conjugates (ADCs), facilitating targeted delivery in cancer therapy. Its use in research applications contributes to the development of innovative therapeutic strategies in oncology.
Product Information
Catalog NumA55038
FormulaC16H27NO2
Molecular Weight265.39
CAS Number870640-61-2
SMILESCN(CC1=CC=CC=C1)[C@H](C(OC)OC)[C@@H](C)CC
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Cytoskeleton > Microtubule/Tubulin