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Monomethyl auristatin E intermediate-13

Catalog No.: A55035
Intermediate Reactant
Monomethyl auristatin E intermediate-13 is a key intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor with demonstrated anticancer activity. MMAE is commonly employed as the cytotoxic component in antibody-drug conjugates (ADCs), enhancing targeted cancer therapy. This intermediate is essential for research applications focused on the development and optimization of ADCs in cancer treatment.
Monomethyl auristatin E intermediate-13 870640-64-5 Intermediate Reactant
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMonomethyl auristatin E intermediate-13 is a key intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor with demonstrated anticancer activity. MMAE is commonly employed as the cytotoxic component in antibody-drug conjugates (ADCs), enhancing targeted cancer therapy. This intermediate is essential for research applications focused on the development and optimization of ADCs in cancer treatment.
Product Information
Catalog NumA55035
FormulaC21H35NO3
Molecular Weight349.51
CAS Number870640-64-5
SMILESCC[C@H](C)[C@H](N(CC1=CC=CC=C1)C)[C@H](OC)CC(OC(C)(C)C)=O
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Cytoskeleton > Microtubule/Tubulin