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Monomethyl auristatin E intermediate-15

Catalog No.: A54834
Intermediate Reactant
Monomethyl auristatin E intermediate-15 is a crucial intermediate in the synthesis of Monomethyl auristatin E (MMAE). MMAE functions as a microtubule and tubulin inhibitor, exhibiting significant anticancer activity. This compound is predominantly utilized as the cytotoxic component in antibody-drug conjugates (ADCs), thereby enhancing targeted cancer therapies. Its role in facilitating the production of MMAE makes it an important reagent for researchers focused on developing innovative cancer treatments.
Monomethyl auristatin E intermediate-15 173653-47-9 Intermediate Reactant
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25mg
$195.00
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50mg
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMonomethyl auristatin E intermediate-15 is a crucial intermediate in the synthesis of Monomethyl auristatin E (MMAE). MMAE functions as a microtubule and tubulin inhibitor, exhibiting significant anticancer activity. This compound is predominantly utilized as the cytotoxic component in antibody-drug conjugates (ADCs), thereby enhancing targeted cancer therapies. Its role in facilitating the production of MMAE makes it an important reagent for researchers focused on developing innovative cancer treatments.
Product Information
Catalog NumA54834
FormulaC20H29NO5
Molecular Weight363.45
CAS Number173653-47-9
SMILESO[C@H]([C@H](C)C(OCC1=CC=CC=C1)=O)[C@H]2N(C(OC(C)(C)C)=O)CCC2
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This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Cytoskeleton > Microtubule/Tubulin