Monomethyl auristatin E intermediate-4

Catalog No.: A55041
Intermediate Reactant
Monomethyl auristatin E intermediate-4 serves as a key intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor exhibiting significant anticancer activity. MMAE is commonly utilized as the cytotoxic component in antibody-drug conjugates (ADCs), enhancing targeted delivery and efficacy in cancer therapy. Researchers use this intermediate for developing ADCs and studying microtubule dynamics in cancer cell biology.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
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Nature volume 574, pages268-272 (2019)
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Nature volume 551, pages639-643 (2017)
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Biological Activity
DescriptionMonomethyl auristatin E intermediate-4 serves as a key intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor exhibiting significant anticancer activity. MMAE is commonly utilized as the cytotoxic component in antibody-drug conjugates (ADCs), enhancing targeted delivery and efficacy in cancer therapy. Researchers use this intermediate for developing ADCs and studying microtubule dynamics in cancer cell biology.
Product Information
Catalog NumA55041
FormulaC20H29NO5
Molecular Weight363.45
CAS Number1823777-46-3
SMILESCCC(C)C(NC(OCC1=CC=CC=C1)=O)C(CC(OC(C)(C)C)=O)=O
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