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Monomethyl auristatin E intermediate-5

Catalog No.: A55053
Intermediate Reactant
Monomethyl auristatin E intermediate-5 is an essential intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor recognized for its anticancer activity. MMAE serves as a key cytotoxic component in antibody-drug conjugates (ADCs), which are increasingly utilized in targeted cancer therapies. The utility of this intermediate supports the development of innovative ADC strategies for effective cancer treatment.
Monomethyl auristatin E intermediate-5 1822810-13-8 Intermediate Reactant
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMonomethyl auristatin E intermediate-5 is an essential intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor recognized for its anticancer activity. MMAE serves as a key cytotoxic component in antibody-drug conjugates (ADCs), which are increasingly utilized in targeted cancer therapies. The utility of this intermediate supports the development of innovative ADC strategies for effective cancer treatment.
Product Information
Catalog NumA55053
FormulaC19H27NO5
Molecular Weight349.42
CAS Number1822810-13-8
SMILESCC(C(NC(OCC1=CC=CC=C1)=O)C(CC(OC(C)(C)C)=O)=O)C
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Cytoskeleton > Microtubule/Tubulin