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Monomethyl auristatin E intermediate-6

Catalog No.: A55051
Intermediate Reactant
Monomethyl auristatin E intermediate-6 serves as a crucial intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor with established anticancer properties. MMAE is recognized for its application as the cytotoxic component in antibody-drug conjugates (ADCs), facilitating targeted cancer therapies. This intermediate is essential for research focused on developing effective ADCs and exploring microtubule dynamics in oncology.
Monomethyl auristatin E intermediate-6 135383-54-9 Intermediate Reactant
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMonomethyl auristatin E intermediate-6 serves as a crucial intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor with established anticancer properties. MMAE is recognized for its application as the cytotoxic component in antibody-drug conjugates (ADCs), facilitating targeted cancer therapies. This intermediate is essential for research focused on developing effective ADCs and exploring microtubule dynamics in oncology.
Product Information
Catalog NumA55051
FormulaC20H29NO5
Molecular Weight363.45
CAS Number135383-54-9
SMILESCC[C@H](C)[C@H](NC(OCC1=CC=CC=C1)=O)C(CC(OC(C)(C)C)=O)=O
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Cytoskeleton > Microtubule/Tubulin