MOR Antagonist 2 Hydrochloride is a selective μ-opioid receptor (MOR) antagonist that effectively penetrates the blood-brain barrier, exhibiting an IC50 of 28.37 nM and a Ki value of 0.18 nM. This compound stabilizes the inactive state of MOR, thereby reducing receptor activation. It has demonstrated efficacy in antagonizing analgesic effects in the mouse warm-water tail-flick test and shows a reduced incidence of withdrawal symptoms in mice subjected to opioid withdrawal. MOR Antagonist 2 Hydrochloride is valuable for research into opioid use disorder and related therapeutic applications.
MOR Antagonist 2 Hydrochloride is a selective μ-opioid receptor (MOR) antagonist that effectively penetrates the blood-brain barrier, exhibiting an IC50 of 28.37 nM and a Ki value of 0.18 nM. This compound stabilizes the inactive state of MOR, thereby reducing receptor activation. It has demonstrated efficacy in antagonizing analgesic effects in the mouse warm-water tail-flick test and shows a reduced incidence of withdrawal symptoms in mice subjected to opioid withdrawal. MOR Antagonist 2 Hydrochloride is valuable for research into opioid use disorder and related therapeutic applications.
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