MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), specifically targeting PDE4A4, PDE4B1, PDE4C3, and PDE4D5 variants. This compound effectively inhibits PGE2-induced cyst formation in MDCK cells, exhibiting an EC50 of 1.2 μM. MR-L2 serves as a valuable tool for studying PDE4-related signaling pathways and exploring potential therapeutic applications in conditions involving dysregulated PDE4 activity.
MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), specifically targeting PDE4A4, PDE4B1, PDE4C3, and PDE4D5 variants. This compound effectively inhibits PGE2-induced cyst formation in MDCK cells, exhibiting an EC50 of 1.2 μM. MR-L2 serves as a valuable tool for studying PDE4-related signaling pathways and exploring potential therapeutic applications in conditions involving dysregulated PDE4 activity.
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