MRS4719 is a potent antagonist of the P2X4 receptor, exhibiting an IC50 value of 0.503 μM in human P2X4 receptor assays. This compound demonstrates neuroprotective effects by reducing infarct volume and promoting neurorehabilitation in models of ischemic stroke. Additionally, MRS4719 effectively decreases ATP-induced intracellular calcium influx in primary human monocyte-derived macrophages, making it a valuable reagent for studying ischemic stroke and related neuroinflammatory processes.
MRS4719 is a potent antagonist of the P2X4 receptor, exhibiting an IC50 value of 0.503 μM in human P2X4 receptor assays. This compound demonstrates neuroprotective effects by reducing infarct volume and promoting neurorehabilitation in models of ischemic stroke. Additionally, MRS4719 effectively decreases ATP-induced intracellular calcium influx in primary human monocyte-derived macrophages, making it a valuable reagent for studying ischemic stroke and related neuroinflammatory processes.
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