MS9024 is a selective degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells through the ubiquitin-proteasome pathway, achieving a DC50 of 35 nM. In additional cell lines, such as MDA-MB-468 and H1299, MS9024 shows DC50 values of 254 nM and 101 nM, respectively. Furthermore, it exhibits inhibitory activity against DNMT1 with an IC50 of 0.43 μM, making it a valuable tool for studying the role of DNMT1 in epigenetic regulation and its implications in cancer research.
MS9024 is a selective degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells through the ubiquitin-proteasome pathway, achieving a DC50 of 35 nM. In additional cell lines, such as MDA-MB-468 and H1299, MS9024 shows DC50 values of 254 nM and 101 nM, respectively. Furthermore, it exhibits inhibitory activity against DNMT1 with an IC50 of 0.43 μM, making it a valuable tool for studying the role of DNMT1 in epigenetic regulation and its implications in cancer research.
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