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Biological Activity
MSI-1436 is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTB1B), with an IC50 of appr 1 μM, 200-fold preference over TCPTP (IC50, 224 μM).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.6 mL | 72.99 mL | 145.97 mL |
| 0.5 mM | 2.92 mL | 14.6 mL | 29.19 mL |
| 1 mM | 1.46 mL | 7.3 mL | 14.6 mL |
| 5 mM | 0.29 mL | 1.46 mL | 2.92 mL |
*The above data is based on the productmolecular weight 685.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21424 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 186139-09-3 |
| Formula | C37H72N4O5S |
| M. Wt | 685.06 |
| Purity | >98% |
| Synonyms | Trodusquemine; Aminosterol-1436, Aminosterol1436, MSI1436, MSI 1436 |
| SMILES | NCCCNCCCCNCCCN[[email protected]@H]1C[[email protected]@](C[[email protected]@H](O)[[email protected]]2([H])[[email protected]]3([H])CC[[email protected]@]4(C)[[email protected]@]2([H])CC[[email protected]@]4([[email protected]](C)CC[[email protected]@H](OS(=O)(O)=O)C(C)C)[H])([H])[[email protected]]3(C)CC1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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