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Myelin Basic Protein

Catalog No.: A46145
PKC Substrate
Myelin Basic Protein (MHP4-14) serves as a specific substrate for protein kinase C (PKC), demonstrating a Km of 7 μM. This synthetic peptide, derived from residues 4-14 of myelin basic protein, is not phosphorylated by various other kinases, including cyclic AMP-dependent protein kinase and casein kinases I and II. It is highly effective for studying PKC activity in crude tissue extracts, providing a low background and reliable results in biochemical assays.
Myelin Basic Protein 126768-94-3 PKC Substrate
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Size Price Stock Qty
5mg
$80.00
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10mg
$125.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMyelin Basic Protein (MHP4-14) serves as a specific substrate for protein kinase C (PKC), demonstrating a Km of 7 μM. This synthetic peptide, derived from residues 4-14 of myelin basic protein, is not phosphorylated by various other kinases, including cyclic AMP-dependent protein kinase and casein kinases I and II. It is highly effective for studying PKC activity in crude tissue extracts, providing a low background and reliable results in biochemical assays.
Product Information
Catalog NumA46145
FormulaC60H103N21O17
Molecular Weight1390.59
CAS Number126768-94-3
SequenceGln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu
Sequence shorteningQKRPSQRSKYL
SMILESC([C@@H](NC([C@@H](NC([C@H](CCC(N)=O)N)=O)CCCCN)=O)CCCNC(=N)N)(=O)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)CCCCN)=O)CO)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CO)=O)CCC1
SynonymsMHP4-14
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TGF-β/Smad > Protein Kinase C (PKC)
Stem Cells/Wnt > Casein Kinase