MYX1715 is a potent inhibitor of N-Myristoyltransferase (NMT) with a KD value of 0.09 nM. This compound effectively inhibits the proliferation of LU0884 and LU2511 cell lines, demonstrating IC50 values of 44 nM and 9 nM, respectively. MYX1715 has shown significant antitumor activity against neuroblastoma and gastric cancer in murine models, and it may be exploited as an antibody-drug conjugate (ADC) toxin for targeted cancer therapies.
MYX1715 is a potent inhibitor of N-Myristoyltransferase (NMT) with a KD value of 0.09 nM. This compound effectively inhibits the proliferation of LU0884 and LU2511 cell lines, demonstrating IC50 values of 44 nM and 9 nM, respectively. MYX1715 has shown significant antitumor activity against neuroblastoma and gastric cancer in murine models, and it may be exploited as an antibody-drug conjugate (ADC) toxin for targeted cancer therapies.
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