N-(Azido-PEG2)-N-Fluorescein-PEG3-acid is a bifunctional PEG-based linker designed for PROTAC synthesis. This compound features an azide moiety that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized molecules. The incorporation of fluorescein facilitates the assessment of conjugation efficiency, enhancing its utility in chemical biology and targeted protein degradation studies.
N-(Azido-PEG2)-N-Fluorescein-PEG3-acid is a bifunctional PEG-based linker designed for PROTAC synthesis. This compound features an azide moiety that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized molecules. The incorporation of fluorescein facilitates the assessment of conjugation efficiency, enhancing its utility in chemical biology and targeted protein degradation studies.
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