N-(Azido-PEG3)-N-bis(PEG3-acid) is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound features an azide group that allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions utilizing DBCO or BCN groups. Its versatility in click chemistry enables efficient labeling and tissue targeting, making it a valuable tool for drug discovery and protein degradation studies.
N-(Azido-PEG3)-N-bis(PEG3-acid) is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound features an azide group that allows it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions utilizing DBCO or BCN groups. Its versatility in click chemistry enables efficient labeling and tissue targeting, making it a valuable tool for drug discovery and protein degradation studies.
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