N-(Azido-PEG3)-N-bis(PEG4-acid) is a versatile PROTAC linker that facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an azide functional group, enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, enhancing the potential for modular design in chemical biology applications.
N-(Azido-PEG3)-N-bis(PEG4-acid) is a versatile PROTAC linker that facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an azide functional group, enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, enhancing the potential for modular design in chemical biology applications.
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