N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a PEG-based linker utilized in PROTAC technology, featuring azide, fluorescein, and carboxylic acid functionalities. This compound serves as a versatile click chemistry reagent capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its unique properties make it suitable for applications in tandem with targeted protein degradation and fluorescent labeling studies in chemical biology.
N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a PEG-based linker utilized in PROTAC technology, featuring azide, fluorescein, and carboxylic acid functionalities. This compound serves as a versatile click chemistry reagent capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its unique properties make it suitable for applications in tandem with targeted protein degradation and fluorescent labeling studies in chemical biology.
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