N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with entities that have DBCO or BCN functionalities. This versatility makes it suitable for various applications in chemical biology and targeted protein degradation research.
N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with entities that have DBCO or BCN functionalities. This versatility makes it suitable for various applications in chemical biology and targeted protein degradation research.
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