N-(Azido-PEG4)-N-bis(PEG4-acid) is a PEG-based linker for PROTAC (proteolysis-targeting chimeras) synthesis. This compound features an azide group that enables click chemistry, participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynyl-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool for bioconjugation and targeted protein degradation applications in chemical biology research.
N-(Azido-PEG4)-N-bis(PEG4-acid) is a PEG-based linker for PROTAC (proteolysis-targeting chimeras) synthesis. This compound features an azide group that enables click chemistry, participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynyl-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool for bioconjugation and targeted protein degradation applications in chemical biology research.
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