Fig. 1 · Structure
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N-Boc-7-aminoheptanoic acid
PROTAC Linker
N-Boc-7-aminoheptanoic acid functions as a PROTAC linker, facilitating the synthesis of targeted protein degradation agents. This compound features an alkane chain with a terminal carboxylic acid and a Boc-protected amino group, allowing for efficient conjugation reactions. The terminal carboxylic acid can form stable amide bonds with primary amines when activated by agents such as EDC or HATU. The Boc group is removable under mild acidic conditions, resulting in the release of the free amine for further applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 60142-89-4 |
| Applications | PROTAC Linker |
| Formula | C12H23NO4 |
| Molecular Weight | 245.32 |
| SMILES | O=C(O)CCCCCCNC(OC(C)(C)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.