N-Boc-8-amino-octanoic acid serves as a versatile linker in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an alkane chain with a terminal carboxylic acid and a Boc-protected amino group, allowing for stable amide bond formation with primary amines in the presence of coupling agents such as EDC or HATU. The Boc group can be easily removed using mild acidic conditions, resulting in the release of the free amine and enabling further modifications in PROTAC development.
N-Boc-8-amino-octanoic acid serves as a versatile linker in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an alkane chain with a terminal carboxylic acid and a Boc-protected amino group, allowing for stable amide bond formation with primary amines in the presence of coupling agents such as EDC or HATU. The Boc group can be easily removed using mild acidic conditions, resulting in the release of the free amine and enabling further modifications in PROTAC development.
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