N-Deacetylthiocolchicine is a potent tubulin inhibitor with an IC50 value of 2.2 nM in multidrug-resistant MDA-MB 231 breast cancer cells. This compound exerts its antiproliferative effects by binding to tubulin, disrupting microtubule assembly, and causing cell cycle arrest during mitosis. N-Deacetylthiocolchicine is a valuable tool for investigating therapeutic strategies in malignancies, particularly breast cancer.
N-Deacetylthiocolchicine is a potent tubulin inhibitor with an IC50 value of 2.2 nM in multidrug-resistant MDA-MB 231 breast cancer cells. This compound exerts its antiproliferative effects by binding to tubulin, disrupting microtubule assembly, and causing cell cycle arrest during mitosis. N-Deacetylthiocolchicine is a valuable tool for investigating therapeutic strategies in malignancies, particularly breast cancer.
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