N-Desmethyl imatinib-d8 is a deuterated metabolite of Imatinib, acting primarily as a selective inhibitor of the c-Abl tyrosine kinase. This compound effectively binds to the c-Abl catalytic domain, inhibiting substrate phosphorylation and thereby modulating c-Abl-mediated α-synuclein activation and related inflammatory signaling pathways. N-Desmethyl imatinib has been shown to induce apoptosis in K562 human leukemia cells and may demonstrate altered pharmacokinetics in gastrointestinal stromal tumor settings following viral infection. It is valuable for research applications in Parkinson’s disease, gastrointestinal stromal tumors, and chronic myeloid leukemia.
N-Desmethyl imatinib-d8 is a deuterated metabolite of Imatinib, acting primarily as a selective inhibitor of the c-Abl tyrosine kinase. This compound effectively binds to the c-Abl catalytic domain, inhibiting substrate phosphorylation and thereby modulating c-Abl-mediated α-synuclein activation and related inflammatory signaling pathways. N-Desmethyl imatinib has been shown to induce apoptosis in K562 human leukemia cells and may demonstrate altered pharmacokinetics in gastrointestinal stromal tumor settings following viral infection. It is valuable for research applications in Parkinson’s disease, gastrointestinal stromal tumors, and chronic myeloid leukemia.
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