N-Mal-N-bis(PEG2-NHS ester) is a polyethylene glycol (PEG) based PROTAC linker designed to enable the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by linking E3 ligases to the desired protein, improving cellular uptake and solubility. Its utility in research applications includes the development of tailored PROTACs for targeted protein degradation studies and therapeutic interventions.
N-Mal-N-bis(PEG2-NHS ester) is a polyethylene glycol (PEG) based PROTAC linker designed to enable the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by linking E3 ligases to the desired protein, improving cellular uptake and solubility. Its utility in research applications includes the development of tailored PROTACs for targeted protein degradation studies and therapeutic interventions.
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