N-Octadecyl-N'-propyl-sulfamide is a selective agonist of peroxisome proliferator-activated receptor alpha (PPARα), demonstrating an EC50 of 100 nM. As an analog of oleoylethanolamide (OEA), it activates PPARα, playing a critical role in lipid and glucose metabolism. In animal models, the compound significantly reduces food intake and body weight gain, with a notable effect observed in both free-feeding Wistar rats and obese Zucker (fa/fa) rats, particularly at doses of 1 mg/kg. Additionally, a dose of 10 mg/kg administered intraperitoneally effectively inhibits appetite and lowers plasma triglyceride levels.
N-Octadecyl-N'-propyl-sulfamide is a selective agonist of peroxisome proliferator-activated receptor alpha (PPARα), demonstrating an EC50 of 100 nM. As an analog of oleoylethanolamide (OEA), it activates PPARα, playing a critical role in lipid and glucose metabolism. In animal models, the compound significantly reduces food intake and body weight gain, with a notable effect observed in both free-feeding Wistar rats and obese Zucker (fa/fa) rats, particularly at doses of 1 mg/kg. Additionally, a dose of 10 mg/kg administered intraperitoneally effectively inhibits appetite and lowers plasma triglyceride levels.
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