Nampt-IN-5 is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), a crucial enzyme in the NAD+ biosynthesis pathway. It demonstrates significant biological activity with cellular IC50 values of 0.7 nM against A2780 cells and 3.9 nM against COR-L23 cells, indicating strong efficacy in targeting cancer metabolism. In addition, Nampt-IN-5 inhibits CYP3A4 activity, making it relevant for studies on drug metabolism and potential interactions. Research applications include cancer cell metabolism and the investigation of therapeutic strategies targeting NAD+ pathways.
Nampt-IN-5 is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), a crucial enzyme in the NAD+ biosynthesis pathway. It demonstrates significant biological activity with cellular IC50 values of 0.7 nM against A2780 cells and 3.9 nM against COR-L23 cells, indicating strong efficacy in targeting cancer metabolism. In addition, Nampt-IN-5 inhibits CYP3A4 activity, making it relevant for studies on drug metabolism and potential interactions. Research applications include cancer cell metabolism and the investigation of therapeutic strategies targeting NAD+ pathways.
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