Nav1.7-IN-8 is a selective inhibitor of NaV1.7, demonstrating a high degree of specificity for this subtype compared to hNaV1.1 and hNaV1.5. It effectively inhibits CYP2C9 and CYP3A4 enzymes with IC50 values of 0.17 μM and 0.077 μM, respectively. Nav1.7-IN-8 exhibits significant analgesic properties, making it a valuable tool for research in pain management and studies related to acute and inflammatory pain pathways.
Nav1.7-IN-8 is a selective inhibitor of NaV1.7, demonstrating a high degree of specificity for this subtype compared to hNaV1.1 and hNaV1.5. It effectively inhibits CYP2C9 and CYP3A4 enzymes with IC50 values of 0.17 μM and 0.077 μM, respectively. Nav1.7-IN-8 exhibits significant analgesic properties, making it a valuable tool for research in pain management and studies related to acute and inflammatory pain pathways.
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