Nebentan is a selective, orally active non-peptide antagonist of the endothelin ETA receptor. It demonstrates significant inhibitory activity against [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptors, with Ki values of 0.697 nM and 569 nM, respectively. Research indicates that Nebentan may effectively mitigate the progression of cor pulmonale and myocardial infarction in vivo, making it a valuable tool for studies related to cardiovascular and pulmonary diseases.
Nebentan is a selective, orally active non-peptide antagonist of the endothelin ETA receptor. It demonstrates significant inhibitory activity against [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptors, with Ki values of 0.697 nM and 569 nM, respectively. Research indicates that Nebentan may effectively mitigate the progression of cor pulmonale and myocardial infarction in vivo, making it a valuable tool for studies related to cardiovascular and pulmonary diseases.
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