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Nedometinib

Catalog No.: A40764
MEK1 Inhibitor
Nedometinib is a selective MEK1 inhibitor, demonstrating an IC50 of 135 nM. By inhibiting phosphorylated ERK (p-ERK) in the MAPK signaling pathway, Nedometinib exhibits notable anticancer activity against squamous cell carcinoma. This compound is valuable for research applications related to dermatosis and neurofibromatosis.
Nedometinib 2252314-46-6 MEK1 Inhibitor
Grouped product items
Size Price Stock Qty
1mg
$50.00
In stock
5mg
$130.00
In stock
10mg
$200.00
In stock
25mg
$330.00
In stock
50mg
$490.00
In stock
100mg
$630.00
In stock
1g
$2,300.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionNedometinib is a selective MEK1 inhibitor, demonstrating an IC50 of 135 nM. By inhibiting phosphorylated ERK (p-ERK) in the MAPK signaling pathway, Nedometinib exhibits notable anticancer activity against squamous cell carcinoma. This compound is valuable for research applications related to dermatosis and neurofibromatosis.
Product Information
Catalog NumA40764
FormulaC17H16FIN4O3
Molecular Weight470.24
CAS Number2252314-46-6
SMILESO=C(C1=C(NC2=CC=C(C=C2F)I)N(C)C3=C1C=CC=N3)NOCCO
SynonymsNFX-179
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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MAPK > MEK